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Exenatide : Keralakaumudi, aug 29,05. front page

Dr Jothydev interviewed by Dr Indrababu

Exenatide belongs to a new class of anti diabetic medications namely Incretin mimetics. Incretins potentiate meal-induced insulin production and secretion by the beta-cells and lower the blood glucose level in the presence of hyperglycaemia. Exenatide is derived from Extendin-4 found in the saliva of Gila monster (Heloderma suspectum) a giant lizard found in some parts of the Americas and Mexico.
This is the only injection other than insulin now available for the treatment of diabetes. Exendin-4 might also have direct effects on beta-cell neogenesis that are independent of insulin demand. The root of administration is subcutaneous (eg 5 mcg/bd). Exanetide is known by the name Byetta and was approved by US -FDA in April 2005.This drug is expected to hit the Indian market by 2007, the main limiting factor being the high cost.

Incretins, DPP-4 inhibitors- Video
kaumudi,aug 29,05
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